February 7th & 8th, 2018
Heart Conference Center, 1st Floor
173 Fort Washington Ave
New York, NY 10032
The symposium on Cancer Genomics and Mathematical Data Analysis, co-organized by Columbia PSOC (Directors Drs Rabadan & Iavarone), MSK CSBC (Directors Dr Leslie & Rudensky), Columbia CSBC (Directors Drs Califano & Honig) and Cornell PSOC (Drs Fischbach-Teschl & Cantley) will present a comprehensive overview of algorithmic and mathematical approaches to the study of cancer through genomic approaches.
Complete Program can be found at https://tinyurl.com/CGMsymp2018
Wednesday, February 7th
Satellite session: Understanding Dream Challenge
Riverview Terrace, Chair: Diana Murray
9.00-9.30 am: coffee/tea & registration
9.30-10 am: Justin Guinney, PhD, Director, Sage Bionetworks:
Introduction to and history of DREAM challenges.
10.00-10.45 am: Dimitris Anastassiou, PhD, Columbia University.
Metagenes: Prognosis of breast cancer and beyond.
10.45-11.00 am: Coffee break
11.00-11.30 am: Michael Stokes, PhD, Columbia University.
Subtype-Selective Lethal Molecules Disrupt the Regulatory Network That Drives Neuroblastoma.
11.30am-12.00 pm: Eugene Douglass, PhD, Columbia University.
The network logic of drug-response and resistance.
12.00-12.45 pm: Discussion led by Sage Bionetworks.
Creating DREAM Challenges based on data from the Centers for Cancer Systems Therapeutic and Topology of Cancer Evolution and Heterogeneity in the Department of Systems Biology at Columbia University Medical Center
Wednesday, February 7th
Session 1: Heart Center auditorium, Chair:
1.15-1.45 pm – Registration
1.45-2.00 pm: Introduction of the 4 Centers co-organizing the Symposium
2.00-2.40 pm: Olivier Elemento, PhD, Weill Cornell Medicine
A cancer precision medicine program driven by multi-omics, analytics and modeling
2.40-3.20 pm: Peter Sims, PhD, Columbia University
Single-Cell Transcriptome Analysis of Lineage Diversity and Microenvironment in High-Grade Glioma
3.20-4.00 pm: Raluca Gordan, Ph.D. Duke University
Quantifying the impact of non-coding mutations on transcriptional regulation
4.00-4.40 pm: Andrea Califano, PhD, Columbia University
Elucidating druggable cancer dependencies on an individual cell basis
Session 2: Riverview Terrace
5.00-8pm: poster session /networking/Wine and cheese
Thursday, February 8th
8.30-9.00 am: coffee/tea & registration
Session 3: Heart Center auditorium, Chair:
9.00-9.40 am: Simon Tavare, PhD, Cancer Research UK Cambridge Institute
Inferring modes of cancer evolution from DNA sequencing data
9.40-10.20 am: Ivana Bozic, PhD, University of Washington
Evolutionary dynamics of cancer and its response to treatment
10.20-11.00 am: Andrew Blumberg, PhD, University of Texas at Austin
Mathematical tools for inference in spaces of phylogenetic trees
11.00-11.20 am: Coffee/tea break
11.20-12.00 pm: Barry Honig, PhD, Columbia University
Using three-dimensional structure to predict protein-protein and protein-ligand interactions
12.00-12.40 pm: Marcin Imielinski, PhD, Weill Cornell Medicine
Recurrent patterns of rearrangement across 3000 cancer graph genomes
12.40-2.00 pm Lunch: on your own
Session 4: Heart Center auditorium, Chair:
2.00-2.40 pm: Joao Xavier, PhD, Memorial Sloan Kettering
Mathematical ecology to predict cancer outcomes
2.40-3.20 pm: Jeff Varner, PhD, Cornell University
Modeling the Integration of Metabolism and Signal Transduction using a Dynamic Constraint Based Approach
3.20-4.00 pm: Ashley Laughney, PhD, Memorial Sloan Kettering
Dissecting tumor cell plasticity and population interactions supporting metastasis using single cell genomics
4.00-4.20 pm: Coffee/tea break
Session 5: Heart Center auditorium, Chair:
4.20-5.00 pm: Andrew Futreal, PhD, MD Anderson Cancer Center
Cancer heterogeneity: challenges and opportunities for clinical impact
5.00-5.40 pm: Michael Shen, PhD, Columbia University
Mouse models of prostate tumor evolution
5.40-6.20 pm: Concluding remarks