Cancer Genomics and Mathematical Data Analysis Symposium

February 7th & 8th, 2018

Columbia University

Heart Conference Center, 1st Floor

173 Fort Washington Ave

New York, NY 10032
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Symposium description
The symposium on Cancer Genomics and Mathematical Data Analysis, co-organized by Columbia PSOC (Directors Drs Rabadan & Iavarone), MSK CSBC (Directors Dr Leslie & Rudensky), Columbia CSBC (Directors Drs Califano & Honig) and Cornell PSOC (Drs Fischbach-Teschl & Cantley) will present a comprehensive overview of algorithmic and mathematical approaches to the study of cancer through genomic approaches.

Complete Program can be found at

For video of the symposium, visit the Rabadan Lab YouTube Channel.


Wednesday, February 7th

Satellite session: Understanding Dream Challenge

Riverview Terrace, Chair: Diana Murray

9.00-9.30 am: coffee/tea & registration

9.30-10 am: Justin Guinney, PhD, Director, Sage Bionetworks:

Introduction to and history of DREAM challenges.

10.00-10.45 am: Dimitris Anastassiou, PhD, Columbia University.

Metagenes: Prognosis of breast cancer and beyond.

10.45-11.00 am: Coffee break

11.00-11.30 am: Michael Stokes, PhD, Columbia University.

Subtype-Selective Lethal Molecules Disrupt the Regulatory Network That Drives Neuroblastoma.

11.30am-12.00 pm: Eugene Douglass, PhD, Columbia University.

The network logic of drug-response and resistance.

12.00-12.45 pm: Discussion led by Sage Bionetworks.

Creating DREAM Challenges based on data from the Centers for Cancer Systems Therapeutic and Topology of Cancer Evolution and Heterogeneity in the Department of Systems Biology at Columbia University Medical Center

Wednesday, February 7th


Session 1: Heart Center auditorium, Chair:

1.15-1.45 pm Registration

1.45-2.00 pm: Introduction of the 4 Centers co-organizing the Symposium

2.00-2.40 pm: Olivier Elemento, PhD, Weill Cornell Medicine

A cancer precision medicine program driven by multi-omics, analytics and modeling

2.40-3.20 pm: Peter Sims, PhD, Columbia University

Single-Cell Transcriptome Analysis of Lineage Diversity and Microenvironment in High-Grade Glioma

3.20-4.00 pm: Raluca Gordan, Ph.D. Duke University

Quantifying the impact of non-coding mutations on transcriptional regulation

4.00-4.40 pm: Andrea Califano, PhD, Columbia University

Elucidating druggable cancer dependencies on an individual cell basis

Session 2: Riverview Terrace

5.00-8pm: poster session /networking/Wine and cheese

Thursday, February 8th


8.30-9.00 am: coffee/tea & registration

Session 3: Heart Center auditorium, Chair:

9.00-9.40 am: Simon Tavare, PhD, Cancer Research UK Cambridge Institute

Inferring modes of cancer evolution from DNA sequencing data

9.40-10.20 am: Ivana Bozic, PhD, University of Washington

Evolutionary dynamics of cancer and its response to treatment

10.20-11.00 am: Andrew Blumberg, PhD, University of Texas at Austin

Mathematical tools for inference in spaces of phylogenetic trees

11.00-11.20 am: Coffee/tea break

11.20-12.00 pm: Barry Honig, PhD, Columbia University

Using three-dimensional structure to predict protein-protein and protein-ligand interactions

12.00-12.40 pm: Marcin Imielinski, PhD, Weill Cornell Medicine

Recurrent patterns of rearrangement across 3000 cancer graph genomes

12.40-2.00 pm Lunch: on your own

Session 4: Heart Center auditorium, Chair:

2.00-2.40 pm: Joao Xavier, PhD, Memorial Sloan Kettering

Mathematical ecology to predict cancer outcomes

2.40-3.20 pm: Jeff Varner, PhD, Cornell University

Modeling the Integration of Metabolism and Signal Transduction using a Dynamic Constraint Based Approach

3.20-4.00 pm: Ashley Laughney, PhD, Memorial Sloan Kettering

Dissecting tumor cell plasticity and population interactions supporting metastasis using single cell genomics

4.00-4.20 pm: Coffee/tea break

Session 5: Heart Center auditorium, Chair:

4.20-5.00 pm: Andrew Futreal, PhD, MD Anderson Cancer Center

Cancer heterogeneity: challenges and opportunities for clinical impact

5.00-5.40 pm: Michael Shen, PhD, Columbia University

Mouse models of prostate tumor evolution

5.40-6.20 pm: Concluding remarks