Workshop on Mathematical Methods in Cancer Evolution and Heterogeneity

June 1-2, 2017

The Simons Center for Systems Biology
Institute for Advanced Study
1 Einstein Dr
Princeton, NJ 08540
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Workshop description

The Workshop on Mathematical Methods in Cancer Evolution and Heterogeneity will present a comprehensive overview of the different mathematical approaches that are currently being developed for the study of cancer evolution and heterogeneity, as well as its clinical implications.


June 1st

9.15-10 am: coffee/tea & registration

10-10.20 am: Introduction: Arnold Levine, PhD (Institute of Advances Study)


Session 1: Chair: Raul Rabadan

10.20-11 am: Dan Landau, MD, PhD (Weill Cornell Medicine)

On the origins of CLL evolution

11-11.40 am: Ben Greenbaum, PhD (Icahn School of Medicine at Mt Sinai)

Quantifying Non-self in Tumors

11.40-12.20 pm: Jinghui Zhang, PhD (St. Jude Children’s Research)

Real-time clonal evolution from diagnosis to relapse in 100 pediatric acute lymphoblastic leukemia


12.30-1.40 pm Lunch: 

Lunch will be available in the Institute Dining Hall. Cash payments only


Session 2: Chair: Pablo Camara

1.40-2.20 pm: Christina Leslie, PhD (MSKCC)

Decoding epigenomic programs governing tumor-specific T cell dysfunction and therapeutic reprogrammability

2.20-3 pm: Nicholas McGranahan, PhD (Cancer Research, UK)

TRACERx: Evolution in Space and Time


3-3.20 pm: Coffee/tea break


Session 3: Chair: Hossein Khiabanian

3.20-4 pm: Christine A. Iacobuzio-Donahue, MD (MSKCC)

Utility of Research Autopsies for Understanding the Evolutionary Dynamics of Cancer

4-4.40 pm: Christina Curtis, PhD (Stanford University)

Quantifying tumor evolution through spatial computational modeling and Bayesian statistical inference

4.40-5.20 pm: Trevor Graham, PhD (Barts Cancer Institute, UK)

Measurement of evolutionary dynamics in human cancers using mathematical modelling of genomic data


June 2nd


Session 4: Chair: Anthea Monod

9.00-9.40 am: Ben Raphael, PhD (Princeton University)

Algorithms for Inferring Evolution and Migration of Tumors

9.40-10.20 am: Sayan Mukherjee, PhD (Duke University)

Melanoma therapeutic strategies that select against resistance by exploiting MYC-driven evolutionary convergence

10.20-11 am: Alexander Anderson, PhD (Moffitt Cancer Center)

Steering cancer evolution: Harnessing phenotypic heterogeneity to design better therapies


11-11.20 am: Coffee/tea break: Bloomberg Hall Biology Atrium


Session 5: Chair: Arnold Levine

11.20- 12 pm: Richard Bonneau, PhD (NYU)

Combining Sequence and Structural features lead to accurate interpretation of genetic variation: large scale modeling and classification of de novo human mutations with VIPUR

12- 12.40 pm: Gunnar Carlsson, PhD (Stanford University)

Topological Data Modeling


12.40-1.30 pm Lunch

Lunch will be available in the Institute Dining Hall. Cash payments only